Abstract
The treatment of male rats with estradiol resulted in an increased hypothermic response to chlorpromazine. This increased pharmacologic response appears to be due to a decreased metabolism of chlorpromazine as indicated by the increased blood levels of S-35 after S-35 chlorpromazine administration and a decreased in vitro metabolism of chlorpromazine by liver microsomes from treated rats. No significant change was observed in the total liver or microsomal protein content. There is indication that decreased NADPH oxidase activity may be involved.
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