Influence of estradiol administration on estrogen receptors of nasal mucosa: an experimental study on guinea pigs

Abstract

IntroductionSome clinical trials revealed a correlation between increased serum estrogen and nasal symptoms or inflammatory changes in nasal mucosa. Estrogen receptors tend to be controlled by a negative feedback, to avoid a deleterious stimulus over several body functions while in hyperestrogenic periods. This study proposes a hypothesis where mechanisms regulating expression of estradiol receptors in nasal mucosa are absent in some patients, and their concentration remains steady even in periods of high serum hormonal concentration, potentially leading to local estrogenic symptoms in nasal mucosa. Study designThis was an experimental prospective study. AimTo determine whether estrogen levels induce the reduction of the number of estrogen receptors in the nasal mucosa. MethodsIn the present study, 30 adult male guinea pigs were subjected to a biopsy of the middle nasal turbinate and received 0.5mL of estradiol cypionate intraperitoneally for 30 consecutive days. Afterwards, samples from contralateral middle turbinate were obtained. Immunohistochemical analysis of estrogen receptors were performed pre- and post-treatment. ResultsThe post-treatment group showed reduction of receptor expression when compared to the pre-treatment group. (p=5.2726-5). ConclusionA reduction in the expression of the nasal estrogen receptor was observed after 30 days of estradiol administration.© 2014 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.