Abstract
Intact, ovariectomized and ovariectomized-adrenalectomized Sprague- Dawley rats, at the age of 50 days, were fed 10 mg of 3-methylcholanthrene (3-MC) by gastric tube 3 or 6 times each week for 7 weeks. Steroids were administered concurrently by the subcutaneous or intramuscular route. Mammary adenocarcinoma was observed in all intact rats. Mean tumor induction time was 52.7 ± 3.9 days for the group injected with sesame oil, 44.1 ± 1.5 for the group injected with progesterone (4 mg) and 47.5 ± 3.9 for the group injected with estradiol-17β (0.01 βg). In rats ovariectomized at 42 days of age, one week prior to treatment with 3-MC and steroids, breast cancer occurred in 63 % of the group injected with sesame oil, in 67 % of the group injected with progesterone, in 12% of the group injected with estradiol-17β and in 81 % of the groups injected with progesterone (4 mg) in combination with estradiol-17β (0.01 or 0.1 βg)- Mean tumor induction time was significantly prolonged in all ovariectomized groups. In rats ...
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