Abstract
The impact of enteric microflora on the expression of genes associated with cocaine and amphetamine addiction was described. Human genome-wide experiments on RNA transcripts expressed in response to three selected Escherichia coli strains allowed for significant alteration (p > 0.05) of the linear regression model between HT-29 RNA transcripts associated with the KEGG pathway:hsa05030:Cocaine addiction after 3 h stimulation with intracellular pathogenic E. coli strain UM146 versus non-pathogenic E. coli Nissle 1917. Among the features influenced by the UM146 bacterial strain were visual learning, response to the presence of morphine, response to hypoxia, behavioral fear response and cognitive functions.
Highlights
Differences in HT-29 cell responses to bacterial strains from the same species complicate understanding the mechanism of bacterial origin
The intracellular human pathogen E. coli UM146 has a stronger impact on the linear trend change than E. coli
One of the most common bacterial species in the human gastrointestinal tract is responsible for the RNA transcript profiles of HT-29 cells related to cocaine addiction
Summary
Citation: Kotłowski, R. Influence of Escherichia coli on Expression of Selected Human Drug AddictionGenes. Life 2021, 11, 1346. https://doi.org/10.3390/life11121346Academic Editor: Cheng-Yen KaoReceived: 22 November 2021Accepted: 3 December 2021Published: 5 December 2021Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Licensee MDPI, Basel, Switzerland.Attribution (CC BY) license (https://creativecommons.org/licenses/by/
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