Abstract
Polycystic ovary syndrome is an observed plurimetabolic syndrome associated with central obesity and insulin resistance. The purpose of the present study was to investigate the effects of 12-week training program on weight loss, serum ghrelin, acylated ghrelin, des-acylated ghrelin, and obestatin levels in obese sedentary women with polycystic ovary syndrome (PCOS). To this end, thirty sedentary obese women with PCOS (mean age 31.07 ± 2.49 years, height 162.23 ± 2.39 cm, weight: 87.23 ± 4.48 kg, BMI 33.12 ± 0.92) were recruited from a multidisciplinary PCOS specialty clinic in Tabriz city in 2017 and evaluated before and after a 12-week training program, including 45 min per session of aerobic training at an intensity of 60–75% of age-predicted maximum heart rate (300 kcal/day). After the exercise program, body weight, waist circumference, and percentage body fat mass were decreased. Also, fasting glucose, insulin, and serum acylated ghrelin levels were significantly decreased (P 0.05). The moderate aerobic exercise training is associated with improvements in obestatin and health profiles of obese women with PCOS without associated structured energy restriction.
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