Influence of enalapril on the functional state of the central nervous system in experimental Alzheimer’s disease

Abstract

The purpose of the work. Is To investigate the effects of enalapril on the functional state of the central nervous system of rats with experimental Alzheimer's disease.Material and methods. Experiments were carried out on non-linear laboratory white male rats weighing 0.18–0.20 kg. A model of Alzheimer's disease was created by intraperitoneal administration for 27 days of scopolamine hydrochloride (Sigma, USA) at a dose of 1 mg/kg. Starting from the 28th day of the experiment, enalapril was administered intraperitoneally at a dose of 1 mg/kg in 1 ml of saline solution — once a day, 14 days. The functional state of the central nervous system was assessed by the behavioral responses of rats in "open field" tests and "conditioned reflex of passive avoidance".Results. Behavioral reactions of rats with Alzheimer's disease after enalapril administration in the "open field" test were characterized by a decrease in the time of "immobility", an increase in the number of urinates and fecal boluses; in the test of the "conditioned reflex of passive avoidance" — an increase in the latent period of the entrance of rats into a darkened compartment connected to the electric current.Conclusions. The established behavior changes in Alzheimer's disease testify to the restoration of emotional reactions, the formation of a conditioned reflex in electrical pain stimulation, and indicate the corrective capacity of enalapril under conditions of neurodegenerative disturbances of the central nervous system.