Abstract
The dissolution behaviors in water of several drugs in solid dispersion with egg albumin have been studied in comparison with drug alone. The results revealed a marked increase of dissolution rate of acidic drug compared with basic drug. The interaction of each drug with egg albumin in aqueous solution and solid state was studied by solubility analysis, thermal analysis and X-ray diffractometry. The solubility of acidic drug was significantly increased with egg albumin concentration. In the solid state, acidic drug dispersed monomolecularly in the matrix of egg albumin. The enhancement of dissolution rate of drug was reflected for the improvement of solubility through complexation and the molecular dispersion of drug in the solid dispersion.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
