Abstract
It has been known that the bone tissue around dental implant adapts to functional load by changes in structure and mass. However, the effects of immediate loading of implants placed into extraction sockets are uncertain. We studied the differences in early bone–biomaterials interaction and reactions between the progressive vertical loading and the nonloading of implants placed into extraction sockets. The progressive loading promoted the bone-implant osseointegration by accelerated mineralization speed many times as faster as the control groups and stimulated preosteoblast attached on the implant surface and differentiated to osteoblast. Osteoblast reacted to immediate loading with advance release of the related protein of osteogenesis. These results show that progressive loading accelerates the new bone formed around the implant and promotes osseointegration.
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