Abstract
Background Duffy antigen receptor for chemokines (DARC) binds inflammatory chemokines including several that also bind to CCR5. A recessive DARC allele which blocks expression on red cells affects ~90% of sub-Saharan Africans but very few people of non-African origin. Approximately 50% of DARC null people show African benign neutropenia. We have investigated whether DARC acts as an HIV co-receptor and whether the null phenotype affects risk of HIV infection.
Highlights
Duffy antigen receptor for chemokines (DARC) binds inflammatory chemokines including several that bind to CCR5
We have investigated whether DARC acts as an HIV co-receptor and whether the null phenotype affects risk of HIV infection
Genotyping of cohorts exposed to HIV-1 with respect to DARC FyA, FyB and Fy null alleles was conducted to assess its affect on neutropenia, CCL5 plasma levels and relative risk of HIV-1 infection
Summary
Duffy antigen receptor for chemokines (DARC) binds inflammatory chemokines including several that bind to CCR5. A recessive DARC allele which blocks expression on red cells affects ~90% of sub-Saharan Africans but very few people of non-African origin. 50% of DARC null people show African benign neutropenia. We have investigated whether DARC acts as an HIV co-receptor and whether the null phenotype affects risk of HIV infection. Doi:10.1186/1742-4690-10-S1-O31 Cite this article as: Weiss: Influence of Duffy antigen receptor for chemokines on HIV infection.
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