Abstract
DNA is an essential element for genetic disease treatments. Its application depends on the diffusive properties of DNA through tissues. Although, there are works on linear DNA diffusion in a network environment, the dependence of the diffusion coefficient on chain architecture is not completely understood.In this work we study dsDNA molecule behavior in a network with the discrete slip-link model. We show dependence of the diffusion coefficient on the chain molecular weight and network mesh size. We compare theoretical predictions with experimental measurements of linear dsDNA thermal diffusion in agarose gels. To analyze the influence of the architecture of the DNA molecule on its diffusion properties, the theory can be applied to star-shaped molecules. However, to obtain experimental data it requires to synthesize a well characterized star-shaped dsDNA molecule.
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