Influence of DS of CMC on morphology and performance of magnetic microcapsules

Abstract

In this paper, we present a reproducible method for the preparation of mixed colloidal nanoparticles, consisting of a magnetic Fe3O4 nanoparticle nucleus and a biocompatible self-assembly shell of substitution of sodium carboxy methyl cellulose and chitosan in different degree. The heterogeneous structure of the particles can confer them both the possibility of being used as drug delivery systems and the responsiveness to external magnetic fields, allowing a selective guidance of drug molecules to specific target tissues without a concurrent increase in its level in healthy tissues. The preparation method is based on a coordination and layers by layers self-assembly process. In order to specify that A complete physicochemical characterization of the composite particles is carried out, in order to use this preliminary investigation to show that the CMC/CS shell efficiently coating Fe3O4 nanoparticles, and leading to composite particles, the magnetic behavior of the core/shell particles is similar to that of bare magnetic Fe3O4 nanoparticles. It is observed that The magnetic microspheres with CMC DS 1.05 served as shell show the best dispersion, super paramagnetic, the range of magnetic field the particles can respond is an order of magnitude higher than others, and the specific saturation magnetization intensity is the highest. Thus we can indicate with the conclusion that if the DS of CMC becomes higher, the Fe3O4@CS/CMC would be more sensitive with the extant magnetic field. However, when the DS of CMC is higher than 1.1, the specific saturation magnetization intensity of magnetic microspheres would fall down again and the geometry becomes not well. Therefore, when the DS of CMC stay in 1.05, it would be a better material of magnetic microsphere.