Abstract
The influences of treatment with drugs, of sex, and of treatment with sex hormones on the liver l-ascorbic acid content in fish were studied. An analysis of various enzymatic steps of the glucuronic acid pathway involved in the synthesis of l-ascorbic acid was made. The data obtained, on most points confirmed the findings in this field obtained with mammals. In mammals the drug-induced increase in the activity of drug-metabolizing enzymes in the liver is accompanied by an increased production of l-ascorbic acid. In fish this drug-metabolizing enzyme inducing activity of drugs is only very slight, while there is a clear response in l-ascorbic acid formation. This makes it doubtful whether there is any direct relationship between the induction of an increased activity of drug-metabolizing enzymes in the liver, and the increased formation of l-ascorbic acid in the liver.
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