Abstract
Influence of dosimetric considerations in evaluating second cancer risks in prostate cancer. Material and methods: Fifteen patients in this study suffering from early stage of prostate cancer, each patient underwent three plans: 1) Three-dimensional conformal radiation therapy (3DCRT), 2) Rotation therapy (Arc therapy), and 3) intensity-modulated radiation therapy (IMRT) plan. Estimate secondary metastasis risk models: Excess Relative Risk (ERR) and Excess absolute risk (EAR) based on age of exposure by taking dosimetry data from Dose Volume Histograms (DVHs) to calculate risk models. Result: The second cancer risk models (ERR and EAR) for organs at risk OARs decrease with increasing age of exposure for 3D-CRT, ARC and IMRT and there is no significant difference for ERR and EAR model for developing second cancer risk in 3D-CRT, ARC and IMRT.
Highlights
Radiotherapy aims to give the prescribed dose to the tumor and to protect as much as possible to organs at risk and surrounded healthy tissue
Result: The second cancer risk models (ERR and Excess Absolute Risk (EAR)) for organs at risk OARs decrease with increasing age of exposure for 3D-CRT, ARC and intensity modulated radiation therapy (IMRT) and there is no significant difference for Excess Relative Risk (ERR) and EAR model for developing second cancer risk in 3D-CRT, ARC and IMRT
1) Dose Volume Histogram was generated to evaluate the mean dose to OARs and tolerance dose according to the Radiation Therapy Oncology Group (RTOG) protocol 0126 dose for rectum, bladder, left and right femoral head
Summary
Radiotherapy aims to give the prescribed dose to the tumor and to protect as much as possible to organs at risk and surrounded healthy tissue. IMRT generates high gradient doses on the target, with rapid drop in the latter to the level of normal structures, result of IMRT technique requires extremely high precision in treatment but with very minor positioning errors can affect the target cover and increase the dose to organs at risk Is It expect that 220,800 new cases of prostate cancer and around 27,540 deaths from estimation at 2015. Studies have shown the benefits of 76 Gy or higher conventionally fractionated treatments, there is a substantial risk of gastrointestinal toxicity, stemming from the rectum dose In these cases, radiation doses better conforming to the prostate are necessary to reduce possible rectal complications [9]
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