Abstract
The effect of the level of DNA fragmentation in the sperm on the development of early embryos in IVF programs for men with low fertility was investigated. A significant negative association between the level of DNA fragmentation in the sperm and the total blastocyst formation rates and a percent of blastocysts with high quality morphology in patients with impaired fertility is proved (rs = -0,59; rs= -0,56). Evaluation of semen quality in men with low fertility is a necessary step before the use of assisted reproductive technologies. The connection between the levels of sperm DNA fragmentation and the peculiarities of the early development of embryos obtained in programs of extracorporal fertilization has been proved. Assessing the quality of sperm in men with reduced fertility is a necessary measure before using auxiliary reproductive technologies. According to literature, the morphology of the blastocyst does not always depend on chromosomal changes in the embryos. Consequently, it is promising to carry out pre-implantation genetic diagnostics of embryos obtained in programs of extracorporal fertilization in patients with high levels of DNA fragmentation in spermatozoa to study the effect of this violation on the karyotype of embryos.
Highlights
Discussions about dissection as a teaching method in gross anatomy are characterised by a lack of objective evidence
Cadaver dissection has been an important component in the traditional method of teaching human anatomy in Medical Faculties
Today many Medical Institutions are facing with practical constraints associated with cadaver dissection
Summary
Discussions about dissection as a teaching method in gross anatomy are characterised by a lack of objective evidence. More sophisticated research designs may be necessary to solve the general problem of the small measurable impact of educational interventions and to come to scientifically sound conclusions about the best way to teach gross anatomy. More educational research in anatomy is necessary to counterbalance emotional arguments about dissection with scientific evidence. Cadaver dissection has been an important component in the traditional method of teaching human anatomy in Medical Faculties. Today many Medical Institutions are facing with practical constraints associated with cadaver dissection. Cadaver dissection takes up a lot of time. This directly conflicts with the changes that have been made in the medical curricula limiting the time available for teaching human anatomy. Anatomy teachers are seeking novel teaching methods to keep up with the changes in the circumstances
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