Abstract
Phenylpropanolamine (PPA) produces weight loss that may result, in part, from an excitatory action of PPA on brown adipose tissue (BAT) thermogenesis. Adult male and female rats were anesthetized with 1.2 g/kg urethane and treated (ip) with either 0.9% saline or 5, 10, 20, or 40 mg/kg dl-PPA. Interscapular BAT (IBAT) and rectal temperatures were recorded every minute for 10 min prior to and 60 min following drug injection. Control rats exhibited stable IBAT and rectal temperatures prior to and after saline injection, whereas PPA-treated rats exhibited in-creases in IBAT temperature and, after a 10-15-min lag, in rectal temperature. There were no differences between male and female rats with regard to the effect of PPA on IBAT and rectal temperature. The implications of these data for an explanation of the weight-reducing effect of PPA are discussed.
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