Influence of Diosmin Treatment on the Level of Oxidative Stress Markers in Patients with Chronic Venous Insufficiency.

Marcin Feldo,Anna Bogucka-Kocka,Jacek Bogucki,Justyna Aszyk,Michał Woźniak,Tomasz Zubilewicz,Ireneusz Sowa,Magdalena Wójciak-Kosior,Agata Kot-Waśik

doi:10.1155/2018/2561705

Abstract

Oxidative stress plays an important role in the pathophysiology of many human disorders, while antioxidants prevent the development of various adverse symptoms. Diosmin is a natural flavonoid applied in vascular system disorders, especially in chronic venous insufficiency (CVI), and it plays a significant part in the alleviation of CVI symptoms. Due to antioxidant activity, it also has the ability to scavenge the oxygen free radicals and hence decreases the level of oxidative stress biomarkers, such as prostaglandins and their precursors—isoprostanes. In the study, the influence of diosmin treatment on the level of isoprostanes in plasma samples of patients suffering from CVI was examined. The qualitative analysis was performed using high-performance liquid chromatography with spectrometry detection (LC-MS). The statistically significant decrease of isoprostane content after 3 months of treatment was observed within the studied group; however, the most significant changes were observed in patients who smoke.

Highlights

IntroductionDiosmin (diosmetin 7-O-rutinoside) is a natural flavone occurring in the Rutaceae family and is especially abundant in the pericarp of various citrus fruits [1]
Diosmin is a natural flavone occurring in the Rutaceae family and is especially abundant in the pericarp of various citrus fruits [1]
Since the measurement of F2-IsoP and their metabolites may be useful to evaluate the effectiveness of clinical therapies applied to diminish oxidative stress associated with inflammation, the aim of the study was to assess the influence of diosmin treatment on the level of isoprostanes (8-iso-15(R)PGF2α; 8-iso-PGF2α; 11β-PGF2α; 15(R)-PGF2α) in patients suffering from chronic venous insufficiency (CVI)

Summary

Introduction

Diosmin (diosmetin 7-O-rutinoside) is a natural flavone occurring in the Rutaceae family and is especially abundant in the pericarp of various citrus fruits [1]. The primary stage of the disease is the result of increased and sustained venous hypertension caused mostly by reflux due to incompetent venous valves. It increases hydrostatic pressure and the blood flow in capillaries. Clinical trials showed that diosmin decreases the level of pain and oedema in patients with CVI because it improves lymphatic drainage and supports microcirculation [7, 8].

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Results

Conclusion