Abstract
The influence of dimethyl sulfoxide (DMSO) on the hemolytic activity of various chemical types of antimicrobial preservatives has been investigated in vitro, using rabbit erythrocytes. Irrespective of the chemical type of preservative, DMSO causes a depression in the hemolytic response of the erythrocytes to the preservative agents. This depression, which is greatest when the DMSO concentration is between 10 and 20%, is dependent upon preservative concentration and time. The degree of the hemolytic depression caused by the presence of DMSO is decreased with an increase in the concentration of the preservative agent or with an increase in the time of exposure. It was concluded that DMSO affects the rate of preservative-induced hemolysis, probably due to a cellular mechanism rather than to an extracellular preservative-DMSO chemical interaction.
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