INFLUENCE OF DIFFUSE NON-TOXIC GOITER ON THE PROBABILITY OF INCREASING THE CHANCES OF COMPLICATIONS DURING PREGNANCY AND CHILDBIRTH

Abstract

Diffuse nontoxic goiter is the most common form of thyroid pathology among women, which is often found during pregnancy.The aim of the study. Evaluate the probability increase the chances of complications during pregnancy and childbirth in women with diffuse non-toxic goiter.Materials and methods. A retrospective analysis of the history of labor was conducted to assess the relationship between the presence of diffuse non-toxic goiter and the occurrence of complications during pregnancy and childbirth. The estimated probability of complications in women with diffuse nontoxic goiter without disturbance functions of the thyroid gland and hypothyroidism of the thyroid gland.Results of the research. In women with diffuse non-toxic goiter, compared with persons without goiter, statistically significantly more often, there are complications during pregnancy and childbirth, accordingly, increases the chance of threat spontaneous abortion (2.77; 95% CI 2.02-3.79) and threat of preterm labor (3.44; 95% CI 2.02-5.85), occurrence of placental dysfunction (6.51; 95% CI 4.80-8.84), growth retardation of the fetus (4.65; 95% CI 2.51-8.61), preeclampsia (1.65; 95% CI 1.05-2.58), iron deficiency anemia (2.55; 95% CI 1.85-3.52), preterm labor (3.71; 95% CI 1.93-7.12), untimely discharge of amniotic fluid (1.84; 95% CI 1.36-2.49) and anomalies of labor activity (3.16; 95% CI 2.15-4.66). In women with diffuse nontoxic goiter without thyroid disturbance, in comparison with women without goiter, the chance of occurrence of placental dysfunction (4.83; 95% CI 3.45-6.77), fetal growth retardation (3.09; 95% CI 1.55-6.15), iron deficiency anemia (1.82; 95% CI 1.26-2.63), anomalies of labor activity (2.13; 95% CI 1.37-3.31), untimely discharge of amniotic fluid (1.64; 95% CI 1.16-2.31). In women with diffuse nontoxic goiter and subclinical hypothyroidism the chance of a threat of abortion (6.78; 95% CI 4.56-10.08) and preterm labor (6.53 95% CI 3.66-11.63), premature delivery (6.88; 95% CI 3.43-13.81), placental dysfunction (11.17; 95% CI 7.30-17.11), growth retardation (7.39; 95% CI 3.79-14.41), preeclampsia (2.20; 95% CI 1.29-3.74), anemia (4.10; 95% CI 2.77 -6.08),untimely withdrawal of amniotic fluid (2.20; 95% CI 1.50-3.23), anomalies of labor (5.24; 95% CI 3.35-8.19) and caesarean section (1.93; 95% CI 1.20-3.12).Conclusion. The presence of diffuse non-toxic goiter in pregnant women increases the chance of complications during pregnancy and in childbirth. The most probable chance of occurrence of complications during pregnancy and childbirth is the presence of diffuse non-toxic goiter on the background of subclinical hypothyroidism.