Abstract
ObjectiveTo develop sustain release metformin hydrochloride nanoparticulate system and study the effect of different viscosity grade ethylcellulose polymers on in vitro characteristics of obtained nanoparticles. Materials and methodsNon-aqueous solvent emulsion evaporation technique was used. Drug and polymer at different ratios were dissolved in methanol and formed nanoparticles under vigorous stirring in Liquid Paraffin Light. ResultsThe obtained nanoparticles sizes were more in high viscosity grade polymer. There encapsulation efficiency was up to 97.88 ± 0.718% in higher drug-polymer ratio. Metformin and ethylcellulose not chemically interacted. All formulations were amorphous. The highest drug-polymer ratio of high viscosity grade polymer was sustained 44.83 ± 0.09 metformin up to 12 h. The release data was best fitted in zero order kinetic. ConclusionSustainability of ethylcellulose was enhanced by increase in apparent viscosity of polymer and extends the metformin in vitro release.
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