Influence of different transfusion pathway in gastrointestinal cancer chemotherapy

Abstract

Objective This study wag to compared the efficacy and toxicity in gastrointestinal cancer chemotherapy with oxaliplatin,leucovorin and 5-fluorouracil when it wad given with PICC line(Peripherally Inserted Central Catheter)combined chemotherapy pump or with peripheral vein catheter catheterization.Methods 58 patients with gastrointestinal cancer were treated by oxaliplatin,leucovofin and 5-fluomuracil.34cases in group A were given with PICC line(Peripherally Inserted Central Catheter)combined chemotherapy pump.The regimen was FOLFOX6 which consisted of 2-hour infusion of oxaliplatin(OXA)(100 ms/m2)and 2-hour infusion of leucovorin(CF)(400 mg/m2)on Day 1,and by5-fluorouracil(5-FU)400 mg/m2)on Day 1 and 46-hour infusion(2.4 g/m2)used by chemotherapy pump.and all chemotherapy drug were siven through PICC.the regimen wag repeated at 2-week intervals.24 crises in group B were given with peripheral vein catheter catheterization.The regimen consisted of infusion of OXA(130 mg/m2)Day 1 and infusion of CF(100 mg/m2)and 5-FU(450 mg/m2)on Day 1～5,the regimen wag repeated at 3-week intervals.The clinical efficacy and adverse events were evaluated.Results The achievement ratio of catheterization in group A wag 93.1%,the detain time wag 5～180 days,average detain time was 62 days,phlebitis developed in 8.8%(3/34),overall gesponse rate(OR)was 47.0%(16/34).The achievement ratio of catheterization in group B wag 88.2%,the detain time was 1-3 days.average detain time wag 2.5 days,phlebitis developed in 20.8%(5/24),overall response rate(OR)wag 37.5%(9/24).The rate of peripheral neuritis,gastrointestinal reaction,and myelosuppression in group A were higher than group B,there were significant different between two group.Conclusions Compared with peripheral vein catheter catheterization,it is more efficacy and less toxieity with oxaliplatin,leucovorin and 5-fluorouracil regimen in treating gastrointestinal cancer with PICC line,and improved quality of life of these patients.It can be popularized. Key words: Gastrointestinal cancer; Peripherally inserted central catheter; Peripheral vein catheter catheterization; Chemotherapy