Abstract
The action of the pesticides aldrin, dieldrin, endrin, heptachlor, as well as DDT and methoxychlor, on the development of fertilized sea urchin eggs was investigated. Whereas dieldrin did not affect development, endrin demonstrated slight effects while aldrin led to greatly abnormal embryos. Heptachlor proved to be more toxic than aldrin and led to abnormal development and lysis of the embryos. DDT also affected development but less than aldrin. Methoxychlor demonstrated toxic effects similar to those observed with heptachlor. Independent of these morphological observations, data on the incorporation of [ 3H]thymidine in early developmental stages were obtained. Unlike all other compounds methoxychlor significantly inhibited deoxyribonucleic acid synthesis. In contrast to the effects produced here, methoxychlor is much less toxic to mammals than DDT. The meaning of these results for practical purposes is discussed.
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