Abstract
Fenbendazole (FBZ) is one of the most widely used drugs in veterinary medicine. Modification of its physicochemical properties, in particular the parameter of solubility, contributes to a change of its biological activity, that is shown on the model of trichinellosis of white mice. The analysis of methods of obtaining new preparations of fenbendazole is presented: solid dispersions of fenbendazole with polymers, as well as the combinations with polymers and succinic acid (SA) and mixed crystals of FBZ with SA. The concentration of the active substance, stability and effect on biological activity were studied.
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Schedule a callMore From: Известия Российской академии наук. Серия биологическая
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