Abstract
The purpose of this study was to morphometrically evaluate the influence of different durations of ovariectomy-induced estrogen deficiency on alveolar bone loss associated with ligature-induced bone loss in rats. Sixty female Wistar rats were randomly assigned to ovariectomy (OVX test group) or sham operation (SHAM control group). The OVX and SHAM groups were each distributed into three subgroups of ten rats each according to the duration of estrogen deficiency (30, 60 and 90 postoperative days). In all groups, for the last 30 days of the experimental period, cotton ligatures were placed around the cervix of the right upper second molar; the contralateral tooth was left unligated to serve as a control. The maxillary bones were removed, and the alveolar bone loss was analyzed by measuring the distance between the cementoenamel junction and the alveolar bone crest at the buccal site of the right upper second molar. A comparison between the ligated and unligated groups verified the presence of ligature-induced alveolar bone loss (p < 0.05). No significant differences were observed among the unligated groups (p > 0.05). A significant increase in bone loss was observed when ligation occurred 90 days after ovariectomy compared with the sham group (p < 0.05). These results demonstrate that long-term estrogen deficiency affects ligature-induced alveolar bone loss.
Highlights
Periodontal disease is an inflammatory disease of the periodontal tissues that is initiated by bacteria in dental plaque and results in the loss of tooth-supporting tissues, including the alveolar bone
The OVX and sham operation (SHAM) groups were each distributed into three subgroups of ten rats each according to the duration of estrogen deficiency (30, 60 and 90 postoperative days)
Capital letters are for OVX; lower-case letters are for SHAM groups
Summary
Periodontal disease is an inflammatory disease of the periodontal tissues that is initiated by bacteria in dental plaque and results in the loss of tooth-supporting tissues, including the alveolar bone. Most elderly people perceive their oral health as important to their quality of life for various physical, social and psychological reasons.[3] Because of the increased life expectancy in many countries, elderly individuals have more opportunities for dental treatment.[4] Some studies suggest a positive relationship between systemic osteoporosis and oral bone loss[5,6] and between osteoporosis and tooth loss.[7,8]. Ovariectomized rats have been used as an animal model to simulate human postmenopausal accelerated bone loss.[9,10] Previous studies have
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
