Abstract
The problems of pesticide toxicity is of great importance where malnutrition is a rampant health problem. Rats fed on synthetic diet (21% & 5% Casein) were given orally 50 mg/Kg Hexachlorocyclohexane (HCH) for three months period. Neurotransmitters measured from the discrete areas of brain showed significant increase of dopamine (DA) and decrease in the levels of 5‐Hydroxytryptamine (5‐HT) and norepinephrine (NE). Acetylcholine (Ach) content in cerebral cortex was increased. Behavioural observations included distance travelled, resting time, ambulatory and Stereotypie movement showed marked changes on optovarimax, while a significant increase (p < 0.001) was noticed in vertical movement of the rats exposed to HCH. Electroencephalograph records showed bursts of spikes with increased wave frequency.
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