Abstract
Objective To evaluate the influence of dietary fiber complex (DFC) on intestinal mucosal barrier in rats with portal hypertension.Methods 60 healthy male Wister rat models with portal hypertension established by composite method of CCl4 and olive oil were randomly divided into four groups:group A (simple model group),group B (fed with Nutrison),group C (fed with Nutrison and DFC,SDF∶IDF =1∶2),group D (fed with Nutrison and DFC,SDF∶IDF =2∶1).Then extracted rats' intestinal mucous membrane protein to test the expression of Occludin protein and induced type carbon monoxide synthase (iNOS) on the 7th day.Results The expression of Occludin protein of group C and D increased (P ＜ 0.05),and the expression of iNOS reduced (P ＜ 0.05); the expression of Occludin protein and iNOS had no statistical significant difference between group C and D (P ＞ 0.05).Conclusion DFC has a protective effect on gut barrier in rats with portal hypertension. Key words: Dietary fiber complex; Intestinal mucosal barrier; Portal hypertension; Rat; Occludin protein; Induced type carbon monoxide synthase
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