Abstract
Lesions in the dorsolateral tegmentum that depleted hypothalamic norepinephrine induced (a) substantial hyperphagia and weight gains in rats maintained on either high-fat or wet-mash diets, (b) moderate overeating and body weight gains in rats maintained successively on 0.4, 0.3, 0.2, and 0.1% quinine high-fat diets, and (c) body weight maintenance at same-diet control levels in rats maintained successively on 0.2, 0.4, and 0.6% quinine wet-mash diets. Similarities and differences of the present findings with reference to previous observations obtained from rats with ventromedial hypothalamic lesions are discussed.
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