Abstract
Abstract In order to test for possible interaction between the effects of age and the effects of depression, 45 patients with unipolar major depression and 118 normal controls ranging in age from 23 to 87 years completed tests of language, verbal and visual memory, copying, and complex psychomotor function. Biphasic regression analyses suggested more accelerated declines with age in the depressed group on tests of naming and complex psychomotor function. However, there were parallel age effects in depressives and controls on tests of verbal and visual memory, and copying. These results are discussed in terms of cognitive and neurobiologic processes that may underlie an interactive relationship between the effects of depression and the effects of age.
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