Abstract
An objective assessment of the morphofunctional characteristics of the state of soft tissues and bone structures adjacent to the dental implant allows to control the dynamics of the processes of osseointegration in the jaw-dental implant system. The aim of the work was to investigate the level of the β-CrossLaps, С-reactive protein (CRP), osteocalcin markers after orthopedic treatment of patients using dental implant supported advanced dental restoration technologies, to perform a biochemical analysis of the oral fluid of patients after restoration using dental implants and new two-part dental implants. In patients of the index group (52 people), the removable prostheses with metal frame and fixing elements or the commercially available dental implant supported removable prostheses were installed. For the patients of the control group (12 people), the commercially available dental implant supported removable prostheses of acrylic plastics were constructed. For all the patients after 6 months the level of β-CrossLaps, CRP, osteocalcin markers in the oral fluid was analysed. In patients of the index group, the average content of β-CrossLaps was 0.0126 ± 0.002 ng/ml, in the control group it was 0.0147 ± 0.002 ng/ml. The average content of the CRP in patients of the index group was 0.358 ± 0.019 mg/l, in patients of the control group it was 0.78 ± 0.01 mg/l. In patients of the index group, the average content of osteocalcin was 1.46 ± 0.25 ng/ml, in the control group it was 1.98 ± 0.31 ng/ml. It has been shown that biochemical markers of the oral fluid can be used to predict complications after the dental implants installation. Restoration with two-part dental implants of modern design is associated with fewer complications.
Highlights
Compliance with ethical standards: the study was approved by the Ethics Committee of Samara State Medical University
To assess the metabolic processes in the bone tissue of patients after orthopedic treatment, we evaluated the osteocalcin content in the oral fluid
CRP analysis is an objective method of screening the inflammatory activity in patients of the control and index groups after dental implantation using commercially available dental implants, two-part dental implants and after orthopedic treatment using improved prostheses
Summary
Compliance with ethical standards: the study was approved by the Ethics Committee of Samara State Medical University (protocol No 2018/196). All patients signed a voluntary informed consent to participate in the study (dental implantation and orthopedic treatment, collection of oral fluid samples). Целью работы было исследовать уровни маркеров β-CrossLaps, С-реактивный белок (СРБ), остеокальцина после ортопедического лечения пациентов с применением усовершенствованных технологий протезирования зубов с опорой на дентальные имплантаты. Для пациентов контрольной группы (12 человек) были изготовлены съемные ортопедические конструкции из акриловых пластмасс с опорой на дентальные имплантаты, выпускаемые серийно. Всем пациентам через 6 месяцев исследовали уровни маркеров β-CrossLaps, СРБ, остеокальцина в ротовой жидкости. У пациентов основной группы содержание β-CrossLaps в среднем составило 0,0126 ± 0,002 нг/мл, в контрольной группе — 0,0147 ± 0,002 нг/мл. В основной группе содержание остеокальцина в среднем составило 1,46 ± 0,25 нг/мл, в контрольной группе пациентов — 1,98 ± 0,31 нг/мл. It allows to prevent errors that can lead to disruption of the processes
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