Abstract
Binary complexes of α-hydroxy acids (L-Tartaric acid and L-Malic acid) with d-electron metal ions (copper, cobalt, nickel) were investigated. Potentiometric measurements have been performed in aqueous solution with computer analysis of the data for determination of the stability constants of complexes formed in the studied systems. The coordination mode of the complexes was defined using spectroscopic methods: electron paramagnetic resonance (EPR), ultraviolet-visible (UV-Vis), circular dichroism (CD), and infrared (IR). Results of the equilibrium studies have provided evidence for the formation of dimers with copper(II) ions and monomers with cobalt(II) and nickel(II) ions.
Highlights
Metal ions, which are found in living organisms, occur at the active sites of numerous enzymes and play a key role in them
Continuing our systematic studies on hydroxy acids, we present here the potentiometric and spectroscopic studies of complex formation in the systems of L-tartaric acid or
Copper(II) ions tend to form dimers, which is confirmed by electron paramagnetic resonance (EPR) spectra
Summary
Metal ions, which are found in living organisms, occur at the active sites of numerous enzymes and play a key role in them. Their complexes are interesting as model compounds of active sites of biological enzymes [1,2,3,4,5,6]. The divalent copper, cobalt, and nickel ions are examples of such metal ions They play vital roles in transport of oxygen, enzyme function, cell growth, numerous enzymatic reactions, and the functioning of the central nervous system [7,8,9,10]. Enzymes containing nickel(II) ions such as urease, hydrogenase, methyl-CoM reductase, and CO dehydrogenase/acetylCoA synthase (CODH/ACS) play a crucial role in the carbon cycle [17,18]
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