Influence of DAP1 Genotype and Psychosocial Factors on Posttraumatic Stress Disorder in Thai Tsunami Survivors: A GxE Approach

Nuntika Thavichachart,Taisei Mushiroda,Puangsoi Worakul,Siriluck Suppapitiporn,Anchalee Prasansuklab,Yusuke Nakamura,Sookjaroen Tangwongchai,Buranee Kanchanatawan,Naoyuki Kamatani,Ongart Charoensook,Michiaki Kubo,Prathan Rutchatajumroon,Chutima Roomruangwong,Atapol Sughondhabirom,Wasun Chantratita,Atsushi Takahashi

doi:10.4236/ojgen.2019.93005

Abstract

Background: Posttraumatic Stress Disorder (PTSD) is a psychiatric disorder found in individuals afflicted by a traumatic event including the natural disaster. “Tsunami” occurred in Andaman coast of Thailand on December 26, 2004, in which 33.6% of survivors were diagnosed as PTSD. This study aimed to explore the single nucleotide polymorphism (SNP). rs267943 genotype is located on chromosome 5 in the intron of the death-associated protein 1 (DAP1) gene and psychosocial factors for PTSD. Methods: Participants (N = 1970) were recruited from volunteers who have complete data both of DAP1 gene and psychosocial factor. Results: Using a binary logistic regression model, significant gene-environment interactions were found for the single nucleotide polymorphism (SNP) rs267943 and psychosocial factors including depression (adj. OR = 6.0, 95% CI = 4.29 - 8.39), neurotic personality (adj. OR = 2.73, 95% CI = 2.18 - 3.42), planning (adj. OR = 1.52, 95% CI = 1.20 - 1.93), use of emotional support (adj. OR = 1.32, 95% CI = 1.21 - 1.94) with statistical significant p < 0.001 and self-distraction (adj. OR = 1.52, 95% CI = 1.15 - 1.85) with statistical significant p < 0.05. Conclusion: This study demonstrated that GxE studies can be utilized to shed light on the origins of PTSD.

Highlights

Acute Stress Disorder (ASD) is one of the forms of traumatic stress which can be developed immediately, following exposure to a traumatic stressor, including, natural disasters
Posttraumatic Stress Disorder (PTSD) is a psychiatric disorder found in individuals afflicted by a traumatic event including the natural disaster
This study aimed to explore the single nucleotide polymorphism (SNP). rs267943 genotype is located on chromosome 5 in the intron of the death-associated protein 1 (DAP1) gene and psychosocial factors for PTSD

Summary

Introduction

Acute Stress Disorder (ASD) is one of the forms of traumatic stress which can be developed immediately, following exposure to a traumatic stressor, including, natural disasters. Distinct environmental factors that are not shared by all PTSD patients are responsible for pathogenesis of PTSD disorder including serious road accidents, violent personal assaults, traumatic births, prolonged sexual abuses, witnessing violent deaths, military combats, being held hostages, terrorist attacks, natural disasters, diagnosis of a life-threatening condition and an unexpected severed injuries or deaths of a close family member or friend. The presence of psychiatric disorders may be associated with both psychosocial and genetic factors that contribute to the aetiology of PTSD symptoms. Posttraumatic Stress Disorder (PTSD) is a psychiatric disorder found in individuals afflicted by a traumatic event including the natural disaster. Results: Using a binary logistic regression model, significant gene-environment interactions were found for the single nucleotide polymorphism (SNP) rs267943 and psychosocial factors including depression

Objectives

Methods

Results

Conclusion