Abstract

Calcitonin (CT) is a peptide hormone, discovered by Copp and colleagues in 1961. It is produced by the parafollicular cells of the thyroid gland in mammals and the ultimobranchial gland of birds and fish. It decreases blood calcium levels and inhibits bone resorption by directly affecting osteoclast activity. CTs of a different origin are used clinically in the treatment of osteoporosis and Paget’s disease, and in the management of hypercalcaemia. Salmon calcitonin (sCT) is about 40 times as potential as human CT in lowering blood calcium levels, and is therefore widely used in formulations for treatment of bone diseases [1–2].

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