Abstract
Dibutyryl cGMP (0 to 100 μg), infused intraventricularly in rats and mice, produced dose-dependent increases in brain cGMP, facilitation of shock-induced rat fighting and predatory cricket-killing, and inhibition of isolation-induced mouse fighting. The changes in rat aggression with 25 μg and in mouse aggression with 50 μg were not related to sedation or motor disturbance, since locomotor activity counts were normal as were brain levels of norepinephrine, dopamine, dihydroxyphenylacetic acid, serotonin, and 5-hydroxyindoleacetic acid. These changes seem to be related to an intracellular action of cGMP and appear to be specific for the guanine cyclic nucleotide.
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