Influence of C-reactive protein change on risk prediction of deep vein thrombosis in total knee arthroplasty patients

Abstract

Objective To investigate the trend of C-reactive protein in patients underwent total knee arthroplasty, and to seek the best time to assess the risk of deep vein thrombosis (DVT) in order to guide clinical nursing. Methods A total of 1 316 patients underwent total knee arthroplasty from January 2015 to December 2017 were studied to observe the occurrence of DVT. Patients were divided into DVT group (n=297) and non-DVT group (n=1 019) . The C-reactive protein was compared between the two groups before operation, 1 to 7 days and 14 days after operation. Results Within 3 months after operation, the incidence of DVT in total knee arthroplasty patients was 22.57% (297/1 316) . Symptomatic DVT occurred in 34 patients during hospitalization and asymptomatic DVT occurred in 263 patients within 3 months after operation. The levels of C-reactive protein in the DVT group were higher than those in the non-DVT group since the 3rd day after operation, and the differences were statistically significant (P<0.05) . Conclusions The level of C-reactive protein in patients with DVT is higher than that in patients without DVT. Medical staff should use various measures to prevent DVT, and dynamically observe changes in C-reactive protein to facilitate the early identification of DVT. Key words: Arthroplasty, replacement, knee; Deep vein thrombosis; C-reactive protein; Risk assessment