Abstract
Several investigators (Ehrich, 1953; Asboe-Hansen & Kaalund-Jørgensen, 1956: and Boseila, 1958) have suggested that the basophil leucocyte and the tissue mast cell have some functional relationship in addition to their morphological similarities. Systemic cortisone administration results in a reduction of the number of the tissue mast cells, as well as degranulation or conglomeration of their granules (Asboe-Hansen, 1950; 1952; Videbæk et al., 1950); and oral cortisone administration induces a fall in the absolute count of circulating basophil leucocytes in man (Code et al., 1954). Injected subcutaneously, cortisone brings about a marked decrease in the total leucocyte count in rats (Hamilton, 1957). A single injection of adrenal cortical extract, corticosterone or cortisol produced lymphopenia in rabbits within few hours (Dougherty & White, 1944). In rabbits, as in rats, the lymphocyte is the predominant circulating white cell, and hence a total leucopenia might be expected along with the lymphopenia. The present investigation
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