Influence of COPD on outcomes of patients hospitalized with heart failure: Analysis of the Spanish National Hospital Discharge Database (2001–2015)

Abstract

ObjectiveTo examine trends in incidence and outcomes of heart failure (HF) hospitalizations among patients with or without chronic obstructive pulmonary disease (COPD) in Spain (2001–2015). MethodsWe used national hospital discharge data to select hospital admissions for HF as primary diagnosis. Incidence, comorbidities, diagnostic and therapeutic procedures, length of hospital stay (LOHS), readmissions rate, costs and in hospital mortality (IHM) was analyzed according to the presence or absence of COPD. Charlson comorbidity index (CCI) was used to assess comorbidity. ResultsWe identified 1,501,811 admissions for HF (19.55% with COPD). Incidence was significantly higher in COPD patients for all years analyzed. We found a significant increase in crude incidence over time in both groups of patients. Overall the incidence was 2.42-times higher among COPD patients (IRR 2.42; 95%CI 2.39–2.46). The joinpoint analysis showed that among men with COPD admissions for HF increased by 2.90% per year. Time trend analyses showed a significant decrease in IHM for both groups. Factors independently associated with higher IHM in both groups included: female gender, higher age, comorbidities according to CCI, longer LOHS and readmissions. The presence of COPD was not associated with a higher IHM in patients hospitalized with HF (OR0.98, 95%CI 0.96–1.01). ConclusionsAmong men suffering COPD the incidence of HF hospitalizations increased from 2001 to 2015. Incidence of hospitalizations was more than twice higher in the COPD population. IHM decreased over time in both groups. Female gender and readmission predict higher IHM. There were no differences in mortality between patients with and without COPD.