Abstract
Objective: To assess the effect of atherosclerosis of the arteries of the lower extremities on the parameters of arterial stiffness in patients with arterial hypertension. Design and method: 120 patients with hypertension: group 1- patients with hypertension and manifested atherosclerosis of the lower limb arteries (AANC), group 2 - with hypertension and asymptomatic AANC, group 3 - with hypertension without AANC. The aortic augmentation index (AIXao), aortic pulse wave velocity (PWVao), the duration of the ejection period (ED) of the left ventricle (LV) and the efficiency index of subendocardial viability ratio (SEVR) were determined. Statistica 12.0 was used for statistical analysis. Results: The values of AIXao (%) in patients of the 1st group (38 [29; 45] %) were significantly higher than those in patients of the 2nd (30 [23;38], p < 0.017) and the 3rd (30 [21;32], p < 0.017) groups, while the indices in the patients of the 2nd and 3rd groups did not differ statistically significantly. In patients of the 1st group higher values of PWVao (11 [10.3;11.9]) were also recorded in comparison with the third group (10.3 [9,6;11.3], p = 0.03). There were no statistically significant differences between the PWVao values in patients of the 1st and 2nd (11 [10.3;11.9] and 10.4 [9.4;11.4], p> 0.05) groups, and also in patients of groups 2 and 3 (p > 0.05). Higher ED values were also determined in patients of group 1 compared with others group. No differences were found when comparing the SEVR (%) in patients of the 2nd and 3rd groups, at the same time, in the patients of the 1st group, the SEVR values were significantly lower as compared with the 2nd group (113 [92;134] and 121 [110;134], p = 0.03), and with the 3rd group (128[106;138], p < 0.017). Conclusions: In patients with hypertension, the development of asymptomatic AANC did not have a significant effect on the parameters of arterial stiffness, together with the presence of concomitant clinically manifested AANC led to an increase in the rigidity of the vascular wall, which indicates a higher risk of cardiovascular complications.
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