Abstract
This study investigates the interactions between clonazepam and concomitant antiepileptic drugs, and the underlying problems associated with collecting and analysing data. The influence of concomitant carbamazepine, phenytoin, valproic acid and zonisamide, on the steady-state serum concentration of clonazepam were investigated by a multiple linear regression analysis in 51 epileptic in-patients under 20 years-of-age, receiving chronic clonazepam monotherapy or polytherapy. The proposed age- and dose-effect model accurately described clonazepam pharmacokinetics (multiple correlation coefficient 0–884), indicating that the serum concentration of clonazepam was positively correlated with the dose of clonazepam and negatively correlated with the dose of carbamazepine and valproic acid, but not of phenytoin or zonisamide, in an age-related manner.
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