Abstract
AbstractColonies of 115 mice each were exposed for 43 days to the ambient outdoor atmosphere of Los Angeles (LA) and Santa Barbara (SB), cities that frequently and infrequently exceed air quality standards, respectively The air monitoring stations closest to the LA and SB vivarial sites provided data on nitrogen dioxide (NO2), ozone (O3, sulfur dioxide, carbon monoxide, hydrocarbons, and particulates. All Los Angeles air pollutants were higher than those in Santa Barbara. In particular, the 1-h average of O3 exceeded the 1985 California state O3 standard of 0.10 ppm on 21 of the 43 days, versus just 2 for Santa Barbara. The NO2 mean for LA was 4 times higher than the SB mean, 0.10 versus 0.03 ppm, respectively Image analysis measurements of Type 2 cells and alveolar walls showed the following greater measurements for the LA animals: (a) numbers of Type 2 cells (p - .05); (b) mean area of Type 2 cells (p -.06); (c) alveolar wall area (p -.001); and (d) alveolar wall perimeter (p - .001). In addition, the r...
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