Influence of Collagen Membranes and Collagenous Sponge Material in the Connective Tissue Matrix During Wound Healing: An Immunohistochemical Study

Abstract

Collagen implant materials have a wide spectrum of clinical applications in medicine and dentistry, especially for bleeding control after surgical procedures [1–4], but also in order to increase tissue quality during wound healing [1, 5]. Although collagen has antigenic properties [6–9] as an implant material, its good biocompatibility and easy application in daily clinical practice make it important for different surgical procedures. The capacity of collagen materials to promote fibroblast Chemotaxis [10], to facilitate early connective tissue and epidermal wound healing [11], and to support periodontal regeneration has been investigated in recent studies [12–15]. The aim of this study is to present the influence of collagen implant materials in the connective tissue matrix during wound healing in rat skin.