Abstract
The aim of this study was to evaluate the effect of coating of alginate-chitosan (AL:CS) beads on the colonic drug delivery. The AL:CS systems containing triamcinolone (TC) were coated with the HPMCP and Eudragit? L100 by immersion and by spraying methods. The drug release profile in simulated colonic medium was determined using 5% human fecal content suspension in 0.01 N buffer solution, pH 6.8. The systems coated with HPMCP showed a lower rate of drug delivery in simulated enteric medium. The delivery profile in simulated colonic medium followed zero-order kinetic. The coated systems provided a promising drug-delivery profile for application in colonic drug delivery.
Highlights
Colon-specific drug delivery has attracted the attention of many researchers interested in the treatment of diseases of that specific location, such as ulcerative colitis and Crohn’s disease, in its potential as a method of protein and peptide delivery, and in the treatment of circadian diseases, such as rheumatoid arthritis and bronchial asthma [1]
The aim of this study was to determine the effect of two gastro-resistant polymer coatings, hydroxypropyl cellulose phthalate and Eudragit L100®, for the AL:CS beads, using different coating methods, on the colon-specific delivery of triamcinolone, a slightly water-soluble corticosteroid used in the treatment of ulcerative colitis
Chitosan was purchased from Purifarma® (Brazil), Hydroxypropyl methylcellulose phthalate (HPMCP) was purchased from Sigma® (Brazil), Eudragit® L100 was purchased from Degussa (Germany), sodium alginate was purchased from Vetec (Brazil) and triamcinolone was purchased from Galena (Brazil)
Summary
Colon-specific drug delivery has attracted the attention of many researchers interested in the treatment of diseases of that specific location, such as ulcerative colitis and Crohn’s disease, in its potential as a method of protein and peptide delivery, and in the treatment of circadian diseases, such as rheumatoid arthritis and bronchial asthma [1]. The use of polysaccharides in the development of drug-delivery systems is based on their abundance, as they are very common, cheap, biodegradable, stable and available in a wide variety of structures, with, a wide variety of physical and chemical properties [5]. Polysaccharides such as chitosan (animal), alginate (marine), pectin (plant), chondroitin sulphate (animal), dextran (microbial) and guar gum (plant) have been used as carriers in colon-specific drug delivery systems [6,7]
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