Influence of clinical and paraclinical variables of the patient in the failure to achieve a pregnancy after embryotransfer: statistical analysis evaluation

Abstract

We conducted this observational prospective study in order to establish to what extent do the clinical and paraclinical characteristics of the patient and the factors that determine infertility also negatively influence pregnancy rate (PR) per embryotransfer. We included 79 women who underwent 145 embryotransfers and we analyzed the positive β-hCG test result. We identified that the following parameters are not statistically significantly correlated to the failure rate: smoking (p=0.7230, OR=1.23), drug use (p=0.7850, OR=1.38), BMI (p=0.4210, OR=1.04), history of infertility, family illness (p=0.3212, OR=1.64), history of miscarriages (p=0.4438, OR=0.61) or abortions (p=0.9842, OR=0.99), previous ectopic pregnancy (p=0.6880, OR=1.30), dyspareunia (p=0.5400, OR=1.43), dysmenorrhea (p=0.4232, OR=0.65), endometriosis (p=0.1150, OR=2.43), impermeable fallopian tubes (p=0.1676, OR=2.11). AMH is not an independent risk factor for pregnancy failure either (p=0.1690, OR=0.79). Age and menarche are risk factors. Age predisposes to a 3.30 times higher failure rate to obtain a pregnancy (calculated cutoff: 34 years old; p=0.0210; OR=3.30). A patient who had menarche before 13 years old (calculated cutoff) has a four times higher risk of failure to obtain a biochemical pregnancy (p=0.0126, OR=3.91). As a conclusion, after reaching the embryo transfer point, the clinical and paraclinical characteristics of the patient are not independent negative factors on PR, except for patient’s age and menarche time.