Abstract
Aim: The authors aimed to identify factors that independently influence the survival of patients with primary clear cell carcinoma of the liver (PCCCL). Methods: A total of 470 patients with hepatocellular carcinoma were retrospectively analyzed. Multivariate Cox analysis was used to identify potential factors associated with prognosis of PCCCL. Results: Patients with PCCCL showed significantly higher disease-free survival (DFS) and overall survival (OS) compared with patients with non-clear cell hepatocellular carcinoma. Multivariate analysis revealed that AFP level, tumor size, liver cirrhosis and portal vein tumor thrombosis were risk factors for DFS. Tumor size, capsule formation and Ki-67 were risk factors for OS. Satellite nodules acted as a protective factor for DFS and OS. Conclusion: PCCCL is associated with betterprognosis in hepatocellular carcinoma. Tumor size and satellite nodules may be independent predictors of OS and DFS.
Highlights
Primary hepatocellular carcinoma (HCC) is, worldwide, the fifth most common cancer and the second most common cause of death from cancer [1]
The presence of clear cell carcinoma was associated with significantly higher disease-free survival (DFS) (P = 0.007) and Overall survival (OS) (P < 0.001)
Multivariate analysis identified the following factors as significantly associated with DFS: alpha-fetoprotein level (AFP), tumor size, liver cirrhosis, satellite nodules and portal vein tumor thrombosis (PVTT)
Summary
Primary hepatocellular carcinoma (HCC) is, worldwide, the fifth most common cancer and the second most common cause of death from cancer [1]. Primary clear cell carcinoma of the liver (PCCCL) is a histological subtype of HCC in which tumors contain at least 50% of cells whose cytoplasm does not stain with hematoxylin or eosin [2, 3]. Approximately 12% of HCC patients have PCCCL or some presence of clear cell carcinoma. Compared to other subtypes of HCC, PCCCL is associated with higher rates of HCV infection, pseudocapsule formation and liver cirrhosis, but a lower rate of vascular invasion [3, 4, 6, 7]. Few studies have examined the prognosis of HCC patients whose clear cell carcinoma falls short of PCCCL. To evaluate whether the presence of clear cell carcinoma in patients with hepatocellular carcinoma affects their prognosis after hepatectomy
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
