Abstract
Diseases of testicles are an important social problem because according to WHO data, the male factor is about 45% in the structure of sterile marriage. Among many pathogenic factors distorting spermatogenic and endocrine function of testicles, acute and chronic circulatory disorders in them play a great role. Recent studies showed that one of the causes of male infertility is chronic ethanol intoxication causing distorted hemomicrocirculation in testicles, so determining the character of cytologic changes in them in these circumstances remains relevant.
 Objects and methods. In the study, we used 14 histological micropreparations from testicular biopsy specimens from middle-aged infertile males (22-35 years) with chronic alcoholism in anamnesis,. In some biopsy specimens, ultrastructural changes in testicles were studied under the electronic microscope, testicular hemodynamics in infertile males was examined with ultrasound.
 Results. In middle-aged infertile males with chronic alcoholism, the volume of testicles decreases compared to normal. The arterial blood flow rate in them decreases significantly. The diameter of tortuous looped seminiferous tubules decreases compared to normal. Their membrane is thickened; the layers of spermatogenic epithelial cells are reduced. The volume of interstitial endocrinocytes decreases compared to normal. Testosterone level in blood decreases too.
 Ultrastructural changes in testicles are manifested with irregular thickness and curving of spermatogenic epithelial basal membrane, vacuolization of myoid cellular, supporting epitheliocytes, and interstitial endocrinocyte cytoplasm with reduced mitochondrial cristae and tubules in the endoplasmic reticulum. In ejaculate of infertile males, sperm concentration decreases to (30.65±1.70) million/ml compared to (75.80±4.20) million/ml, the number of pathologic forms of spermatozoids increases twice, the number of spermatozoids with progressive movement decreases.
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