Abstract
The effect of chronic administration of chloroquine on leydig cells and plasma testosterone level was examined. Twenty-five albino Wistar rats were divided into five groups –– A, B, C, D and E. Group A animals received a normal dose of 0.57mg per kg body weight of chloroquine for 3 days. Groups B, C and D received chronic doses of 0.57 mg per kg body weight of chloroquine for 4, 5 and 6 days respectively. Group E animals, which served as control, were administered normal saline. Historical examination of the process sections of groups B, C and D indicated numerical reduction of the leydig cells when compared with the control group. Group A appeared normal. The basement membrane of the seminiferous epithelium in groups C, C and D were disrupted, leading to the detachment of many spermatocytes. Groups B, C and D recorded reduced level of plasma testosterone when compared with the control group. However, the concentration of plasma testosterone in group A (2.15 1.63g/ml) and control (2.40 ± 1.48g/ml) were similar. Chromic administration of chloroquine reduced the number of leydig cells with concomitant reduction of testosterone production. It also disrupted seminiferous epithelium, leading to the detachment of spermotocytes. (Afr J Reprod Health 1999; 3 [2]: 97-101) Key Words: Chloroquine, leydig cells, testosterone, seminiferous epithelium
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