Abstract
BackgroundHyperuricemia is closely related to renal diseases. Therefore, the aim of this study was to explore the relationship between the longitudinal changes in serum uric acid and the estimated glomerular filtration rate (eGFR) in a cohort of elderly hypertensive patients.MethodsEighty hundred and thirty-seven re-hospitalized patients with hypertension were included in this retrospective cohort study. Multiple regression analysis was used to investigate the relationship between changes in serum uric acid and renal function after 3.5 years follow-up.ResultsThe average age at baseline was 69.0+/-10.0 years, and the average follow-up duration was 3.5 years. Multiple linear regression analysis showed that the baseline uric acid levels had a linearly negative correlation with baseline eGFR (P < 0.01), after adjustment for age, gender, blood pressure, and body mass index, et al. An increase of 100 μmol/L baseline uric acid level resulted in a decrease of 5.684 ml/min/1.73 m2 in eGFR [95 % confidence interval (CI): 7.735-3.633]. Patients with increased uric acid levels had higher risk of renal function decline over the follow-up period, with an adjusted odds ratio of 1.639 (95 % CI: 1.129-2.378, P = 0.009) , whereas eGFR was remained unchanged in patients with hyperuricemia at baseline and with normal uric acid level 3.5-year later.ConclusionsLongitudinal changes in uric acid levels were independently associated with the renal function decline in elderly patients with hypertension. Uric acid level should be considered in hypertension management in the elderly.
Highlights
Hyperuricemia is closely related to renal diseases
Our earlier study found that hyperuricemia was an independent risk factor for poor control of blood pressure during hospitalization in elderly patients with hypertension [11], and subjects in our study were much older and had more comorbidity compared with that in the study of Ohta Y et al the aim of this study was to determine whether longitudinal changes in uric acid level were associated with the renal function in this cohort of elderly hypertensive patients
To the best of our knowledge, this was the first study focused on whether a decrease in serum uric acid might slow down the progression of renal damage in elderly patients with hypertension, independent of age, diabetes, and chronic kidney disease
Summary
Hyperuricemia is closely related to renal diseases. the aim of this study was to explore the relationship between the longitudinal changes in serum uric acid and the estimated glomerular filtration rate (eGFR) in a cohort of elderly hypertensive patients. Our earlier study found that hyperuricemia was an independent risk factor for poor control of blood pressure during hospitalization in elderly patients with hypertension [11], and subjects in our study were much older and had more comorbidity compared with that in the study of Ohta Y et al the aim of this study was to determine whether longitudinal changes in uric acid level were associated with the renal function in this cohort of elderly hypertensive patients. To the best of our knowledge, this was the first study focused on whether a decrease in serum uric acid might slow down the progression of renal damage in elderly patients with hypertension, independent of age, diabetes, and chronic kidney disease. The result may play an important clinical role in the preservation of renal function for elderly patients with hypertension
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