Abstract
The influence of certain pharmaceutical materials on the photostabilizing effect of uric acid for solutions of FD&C Blue No.2 was investigated. Uric acid in a concentration of 2.5 mg % was found to excercise its effect as a photoprotective agent in presence of DL-methionine, DL-leucine, Tween 80, lactose, sodium benzoate and methyl-paraben. These materials were noted to accelerate the rate of fading of the dye solutions. On the other hand, uric acid appeared to be practically ineffective in presence of sodium edetate and tartaric acid, Uric acid demonstrated the greatest photoprotective action in presence of sodium benzoate or methylparaben.
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