Abstract
Background: Neural stem cells (NSCs) are a promising source for cell replacement therapies. Intraventricular administration of NSCs offers a non-traumatic transplantation method into the CNS. Recently has been demonstrated that human NSCs injected into the Cisterna magna of an ALS mouse model did not migrate into brain tissue in sufficient amount. A negative influence of cerebrospinal fluid (CSF) on the survival rate of NSCs was discussed. Here, we studied the behaviour of rodent foetal NSCs (rfNSCs) in CSF during expansion and differentiation.
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