Abstract
The interaction of sulphathiazole and succinylsulphathiazole with Compactrol ®, TabBase ®, Emdex ® and lactose granules was studied. Carriers with a high capacity to adsorb moisture caused a significant increase in the adhesion when the mixtures were stored under high humidity conditions. The effect was attributed to capillary interaction following liquid bridge formation between the drug and carrier surfaces. Oven drying of the moist mixtures further increased the degree of adhesion probably due to solid bridge formation.
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