Influence of Cardiopulmonary Bypass on Some Antioxidants and Haematological Measurements in Cardiac Patients and Associated Diseases

Aboudiah, E,Abdel Rachied, G,Mohammed, A,Farrag, A

doi:10.21608/eajbsc.2021.166203

Abstract

cardiopulmonary bypass risk on blood picture and cardiac functions in patients with an open heart and associated diseases. The study was conducted in five groups, twenty healthy people and eighty patients from cardiac surger

Highlights

Induced myocardial ischemia, transient provokes the release of potentially toxic oxygen free radicals as part of a complex inflammatory cascade that progresses toward the site of the tissue injury (Castillo et al, 2005)
The complete blood count and antioxidants were measured in these groups, and the results showed a significant decrease in hemoglobin and red blood cells count on the first and second days after the operation at all ages
A significant increase in white blood cells count, MDA, nitric oxide (NO) level and Glutathione peroxidase (GPX) enzyme activity was observed in patients with cardiac disease associated with diabetes, hepatitis and renal failure at the first and second days after the operation compared to the control groups

Summary

Introduction

Induced myocardial ischemia, transient provokes the release of potentially toxic oxygen free radicals as part of a complex inflammatory cascade that progresses toward the site of the tissue injury (Castillo et al, 2005). Cardiopulmonary bypass (CPB) is a technique that temporarily takes over the function of the heart and lungs during surgery, maintaining the circulation of blood and the oxygen content of the body. This technique has been a revolutionary innovation in medical science that has allowed cardiac surgeons to perform various complicated pen heart surgeries, such as valve replacement, repair of congenital anomalies, coronary bypass surgery, and repair of some large aneurysm. Ischemic reperfusion injury, and neutrophil activation that develop during CPB have a primary role in the formation of oxidative stress. This situation can modify the clinical results by affecting the functions of organs such as lungs and kidneys and primarily the myocardium. This situation can modify the clinical results by affecting the functions of organs such as lungs and kidneys and primarily the myocardium. (Mustafa et al, 2015)

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Results

Conclusion