Abstract
Female rats were continuously exposed to 250 ppm carbon monoxide (CO) or to clean air as controls for 21 days. There was a significant increase in wet lung weight in the exposed animals. Since prolonged CO inhalation results in considerable tissue hypoxia, but only slight lowering of arterial pO 2 and no appreciable change in pO 2 in the lungs, tissue hypoxia remote from the lungs stimulates lung growth in addition to other mechanisms discussed in the text.
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